Cytotoxic activity and related mechanism of the prenylflavonoids isolated from Mallotus conspurcatus croizat.
CHEMISTRY & BIODIVERSITY(2019)
摘要
Five prenylflavonoids, 6-prenylnaringenin (1), 8-prenylnaringenin (2), 7-O-methyl-8-prenylnaringenin (3), 7-O-methyl-6-prenylnaringenin (4), and 4 '-O-methyl-6-prenylnaringenin (5), were isolated from the traditional herb Mallotus conspurcatusCroizat (Euphorbiaceae). Compounds 1-5 revealed cytotoxic activity against cervical cancer (HeLa) cells with IC50 values ranging from 10.08 to 60.16 mu m by MTT method, and interestingly, these prenylflavonoids were less toxic to normal HL-7702 cells. Furthermore, compounds 1 and 5 could inhibit the c-myc expression and telomerase activity and cause mitochondrial dysfunction. These findings might contribute to a better understanding of the biological activities of prenylflavonoids and lay the foundation for further studies on the cytotoxic activity of natural products isolated from M. conspurcatus.
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关键词
Mallotus conspurcatus,4 '-O-methyl-6-prenylnaringenin,cytotoxic activity,telomerase activity,cell apoptosis,phytochemistry
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