De novo gene signature identification from single-cell RNA-seq with hierarchical Poisson factorization

Hanna Mendes Levitin
Hanna Mendes Levitin
Yim Ling Cheng
Yim Ling Cheng
Francisco Jr Ruiz
Francisco Jr Ruiz
Erin C Bush
Erin C Bush

MOLECULAR SYSTEMS BIOLOGY, 2019.

Cited by: 0|Bibtex|Views92|DOI:https://doi.org/10.15252/msb.20188557
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Other Links: pubmed.ncbi.nlm.nih.gov|academic.microsoft.com

Abstract:

Common approaches to gene signature discovery in single-cell RNA-sequencing (scRNA-seq) depend upon predefined structures like clusters or pseudo-temporal order, require prior normalization, or do not account for the sparsity of single-cell data. We present single-cell hierarchical Poisson factorization (scHPF), a Bayesian factorization m...More

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