Live attenuated enterotoxigenic Escherichia coli (ETEC) vaccine with dmLT adjuvant protects human volunteers against virulent experimental ETEC challenge.

Clayton Harro,A Louis Bourgeois,David Sack,Richard Walker,Barbara DeNearing,Jessica Brubaker,Nicole Maier,Alan Fix,Len Dally,Subhra Chakraborty,John D Clements, Ingelise Saunders,Michael J Darsley

Vaccine（2019）

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摘要

The results of this study support further development of ACE527 + dmLT as a vaccine for children in endemic countries and travelers. This is the first clinical demonstration that dmLT can contribute significantly to vaccine efficacy and may warrant testing with other oral vaccines. (ClinicalTrials.gov registration: NCT01739231).

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