Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention of Recurrent Cardiovascular Events in a Real-World Cohort of Post-Acute Myocardial Infarction Patients.

Background: Patients who survive myocardial infarction (MI) are at risk of recurrent cardiovascular (CV) events. This study stratified post-MI patients for risk of recurrent CV events using the Thrombolysis in Myocardial Infarction (TIMI) Risk Score for Secondary Prevention (TRS 2 degrees P). Methods and Results: This was an observational study that applied TRS 2 degrees P to a consecutive cohort of post-MI patients. The primary outcome was a composite endpoint of CV death, non-fatal MI, and non-fatal ischemic stroke. A total of 1,688 post-MI patients (70.3 +/- 13.6 years; male, 63.1%) were enrolled. After a mean follow-up of 41.5 +/- 34.4 months, 405 patients (24.0%) had developed a primary outcome (9.3%/year) consisting of 278 CV deaths, 134 non-fatal MI, and 33 non-fatal strokes. TRS 2 degrees P was strongly associated with the primary outcome. The annual incidence of primary composite endpoint for patients with TRS 2 degrees P 0 was 1.0%, and increased progressively to 39.9% for those with TRS 2 degrees P >= 6 (HR, 27.6; 95% CI: 9.87-77.39, P<0.001). The diagnostic sensitivity of TRS 2 degrees P for the primary composite endpoint was 76.3% (95% CI: 72.1-80.5%). Similar associations were also observed between TRS 2 degrees P and CV death and non-fatal MI, but not non-fatal ischemic stroke. Conclusions: TRS 2 degrees P reliably stratified post-MI patients for risk of future CV events.