Inhibition of catecholamine degradation ameliorates while chemical sympathectomy aggravates the severity of acute Friend retrovirus infection in mice

Dominique Bloemker,Sina Mollerus,Kathrin Gibbert,Ulf Dittmer,Adriana del Rey,Manfred Schedlowski,Harald Engler

Brain, Behavior, and Immunity（2016）

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摘要

•Friend virus (FV) infection caused a transient depletion in splenic noradrenaline.•Expression of catecholamine degrading enzymes was upregulated in splenocytes.•Inhibition of MAO-A and COMT reduced viral load and virus-induced splenomegaly.•Sympathectomy aggravated viral pathology and extended the duration of the disease.

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关键词

Sympathetic nervous system,Noradrenaline,Catecholamines,Friend retrovirus,Retroviral infection,Chemical sympathectomy,MAO-A,COMT

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