Nucleic acid separations using superficially porous silica particles.

Elizabeth D. Close,Alison O. Nwokeoji, Dafydd Milton,Ken Cook, Darsha M. Hindocha, Elliot C. Hook,Helen Wood,Mark J. Dickman

Journal of Chromatography A（2016）

引用 29|浏览7

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摘要

•Superficially porous silica particles enable high resolution separation of nucleic acids.•The pore size of the C18 superficially porous silica particles significantly effects resolution.•Optimum separations of small oligonucleotides obtained with 80Å pore sizes.•Optimum resolution of oligonucleotides (>19mers) was observed with pore sizes of 150Å.•Improved resolution of larger dsDNA/RNA molecules was achieved with pore sizes of 400Å

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关键词

Ion pair reverse-phase chromatography,Nucleic acids,RNA,Oligonucleotides

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