Association between Moderate-Intensity Physical Activity and Inflammatory Markers in Women With and Without Breast Cancer. -
International Journal of Health Sciences and Research(2016)
摘要
Background: Moderate-intensity physical activity has been associated with a lower risk of chronic diseases such as breast cancer. Low-grade chronic inflammation is associated with metabolic disorders and cancer. Purpose: We evaluated the association between self-reported moderate-intensity physical activity and serum levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and C-reactive protein (CRP) in women with and without breast cancer.Methods: We studied a random subsample of 352 cases and 381 controls obtained from a large population based case-control study. An in-person interview, anthropometric measurements and blood samples were obtained. For the analyses, multiple linear regression models were used.Results: In controls, there was a negative association between moderate-intensity physical activity and serum levels of IL-6 and CRP (β = -0.0041, 95% CI -0.0079 to -0.0003; β = -0.0088, 95% CI -0.0172 to -0.0005, respectively); no association was found with serum TNF-α levels. In cases, no statistically significant associations were found.Conclusions: Engaging in moderate-intensity physical activity was independently associated with lower serum concentrations of IL-6 and CRP only in women without breast cancer. Prospective studies are required in order to understand in which moment this association is lost.
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