Circulating Biomarkers Of B Vitamins In Relation To Lung Cancer Risk In The Lung Cancer Cohort Consortium

Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PABackground - B vitamins and factors related to one-carbon metabolism help to maintain DNA and regulate gene expression. Some epidemiological data suggest that factors related to the one-carbon metabolism are important in the pathogenesis of several cancers, including lung cancer.Methods - Within the NCI Cohort Consortium, we designed a prospective case-control study including a total of 5,546 case-control pairs nested within 20 prospective cohorts. Centralized biochemical analyses of all study participants were performed to measure circulating concentrations of vitamin B6, folate and methionine, which were subsequently evaluated in relation to lung cancer risk using conditional logistic regression models.Results - We observed an overall increased risk of lung cancer of 25% among study participants having a deficiency in circulating B6 concentrations compared to those with normal concentrations, the odds ratio (OR) being 1.23 95% confidence interval [CI] = 1.10 - 1.38. This association was primarily evident seen among men (OR 1.38 95% CI 1.20 - 1.60), but not among women (OR 1.03 95% CI 0.85-1.24), as well as for ever ever smokers (OR 1.32 95% CI 1.10 - 1.60). Subgroup analyses by histological sub-site indicated particularly strong association for squamous cell carcinoma type, with about 50% risk increase overall when comparing subjects with vitamin B6 deficiency to normal levels. No association was evident for methionine. Detailed results will be presented at the conference.Conclusion - Our results are compatible with the hypothesis that vitamin B6 deficiency is associated with increased lung cancer risk, although the risk increase appears to be moderate.Citation Format: Anouar Fanidi, David.C Muller, Ross Prentice, Albanes Demetrius, Jian-Min Yuan, Victoria Stevens, Stephanie J Weinstein, Mattias Johansson, Paul Brennan, Lung Cancer Cohort Consortium (LC3). Circulating biomarkers of B vitamins in relation to lung cancer risk in the Lung Cancer Cohort Consortium. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 933. doi:10.1158/1538-7445.AM2015-933