Ribonuclease A as Effective Promoter for Unimolecular Invasion of Peptide Nucleic Acid to Double-stranded DNA
CHEMISTRY LETTERS(2016)
摘要
With the use of ribonuclease A (RNase A) as promoter, only one strand of peptide nucleic acid (PNA) efficiently invades double-stranded DNA (dsDNA), according to the Watson Crick rule. The RNase A locally rewinds the dsDNA to facilitate unimolecular invasion, which otherwise hardly occurs. Furthermore, the single-stranded portion, formed at the invasion site in the dsDNA, is trapped by the protein.
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关键词
Unimolecular invasion,Ribonuclease A,Peptide nucleic acid
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