An Investigation of the Leukaemia Initiating Cell in Trib2 Mediated Aml

TRIB2, a member of the tribbles family of pseudokinases, is an oncogene implicated in a variety of cancers including T-ALL, liver cancer, cervical cancer and lung cancer. Using a murine bone marrow transplant model, we have shown that TRIB2 overexpression in the haemopoietic system leads to the development of a severe AML with a 6-month latency. As the origin of the leukaemia initiating cell (LIC) is unknown and likely to depend on many factors, we aim to identify the LIC in AML for potential targeted treatment.