Bgb324 Represents An Axl And Bcr-Abl1 Inhibitor With Activity In The T315i Mutant
BLOOD（2014）
摘要
BCR-ABL1 inhibitors have revolutionized the treatment of CML patients. However several drawbacks remain, including clinical resistance of T315I-mutated CML. Further, the clinical success of ponatinib, a selective inhibitor of T315I-mutated BCR-ABL1 is hampered by vascular side effects. Therefore, novel treatment strategies are warranted especially in T315I-mutated CML.
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