8-Oxoguanine DNA glycosylase1–driven DNA repair—A paradoxical role in lung aging

Peter German,David Saenz,Peter Szaniszlo,Leopoldo Aguilera-Aguirre,Lang Pan,Muralidhar L. Hegde,Attila Bacsi,Gyorgy Hajas,Zsolt Radak,Xueqing Ba,Sankar Mitra,John Papaconstantinou,Istvan Boldogh

Mechanisms of Ageing and Development（2017）

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摘要

Visual illustration for role of OGG1-BER in senescence/aging processes. In this model OGG1-BER and generation of OGG1•8-oxoG complex (a guanine nucleotide exchange factor) increases levels of activated small GTPases. Downstream from small GTPases transcription factors (TFs) are activated leading to differential expression of mediators and “fueling” senescence/aging processes as shown by gene ontology enrichment and visualization analysis. P values of biological processes are depicted by colors.

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关键词

8-oxoG,8-oxodG,BER,DNA dsbs,DNA ssbs,GEF,GOrilla,HDLF,HRAS,KRAS,MAPK,MEF,NRAS,OGG1,OGG1-BER,PDL,PI3K,ROS,RS,CASAVA,GENE-E,GEO,GO,PANTHER,RPKM,RNA-Seq

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