Antidepressants and gabapentinoids in neuropathic pain: Mechanistic insights

Mélanie Kremer,Eric Salvat,André Muller,Ipek Yalcin,Michel Barrot

Neuroscience（2016）

引用 200|浏览18

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摘要

•Antidepressants and gabapentinoids are first line treatments for neuropathic pain.•Chronic treatment in models of neuropathic pain provided mechanistic insights.•Gabapentinoids target the α2δ-1 subunit of voltage-dependent calcium channels.

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关键词

CREB,DOP,EFNS,IASP,IL,KOP,MOP,NET,NeuPSIG,PCPA,RGS,SERT,SSNRIs,SSRIs,TCAs,TNF-α,VDCC

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