Mycoloyltransferases: A large and major family of enzymes shaping the cell envelope of Corynebacteriales
Biochimica et Biophysica Acta (BBA) - General Subjects(2017)
摘要
Mycobacterium and Corynebacterium are important genera of the Corynebacteriales order, the members of which are characterized by an atypical diderm cell envelope. Indeed the cytoplasmic membrane of these bacteria is surrounded by a thick mycolic acid-arabinogalactan-peptidoglycan (mAGP) covalent polymer. The mycolic acid-containing part of this complex associates with other lipids (mainly trehalose monomycolate (TMM) and trehalose dimycolate (TDM)) to form an outer membrane. The metabolism of mycolates in the cell envelope is governed by esterases called mycoloyltransferases that catalyze the transfer of mycoloyl chains from TMM to another TMM molecule or to other acceptors such as the terminal arabinoses of arabinogalactan or specific polypeptides.
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关键词
aa,AG,Ag85,DEP,DTT,ESI-MS,Fbp(s),FITC,HTS,INH,mAGP,Mar,(c,r)Myt(s),PG,RMSD,RND,TAT,TMM,TDM
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