Refined clinical scoring in comparative EAE studies does not enhance the chance to observe statistically significant differences.
EUROPEAN JOURNAL OF IMMUNOLOGY(2016)
摘要
Considering the 3R rules of animal experimentation, we asked if refined scoring of experimental autoimmune encephalomyelitis (EAE) in mice improves documentation of clinical EAE allowing to perform a more powerful statistical analysis. Surprisingly, refined EAE scoring failed to improve statistical outcome comparing the overall disease courses between two groups of mice.
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关键词
Area under the curve,Bland-Altman plots,Clinical scoring,Experimental autoimmune encephalomyelitis,Statistical analysis
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