Modulation of Biogenic Amines on Intestinal Signaling Proteins and Its Detection.

Abstract Biogenic amines in gastrointestinal tract are the important metabolites of dietary protein and amino acids under the help of gut digestive enzymes and microbes, which play a crucial role in the regulation of intestinal functions, including digestion, absorption, and local immunity. However, high concentrations of biogenic amines can induce adverse reactions and are harmful to animal health. Therefore, it is crucial to have a clear understanding of how different biogenic amines interact with body intestinal function signaling pathway and to monitor the content of biogenic amines in the gastrointestinal tract. And in turn, the proper concentration of dietary protein and balanced amino acids for humans and livestock could be given. Though numerous methods have been developed and improved for the detection of biogenic amines in foods or wines，much less attention was paid straightly on the determination of amines level in gastrointestinal tract. In this article, we mainly focus on the interaction of amines with intestinal function signaling pathway and the broad impacts on animal physiology, and our modified method to accurately and quickly detect the biogenic amines in the digests of animal intestine.