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Activation Of The Yeast Ubi4 Polyubiquitin Gene By Zap1 Transcription Factor Via An Intragenic Promoter Is Critical For Zinc-Deficient Growth

JOURNAL OF BIOLOGICAL CHEMISTRY, no. 36 (2016): 18880-18896

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Stability of many proteins requires zinc. Zinc deficiency disrupts their folding, and the ubiquitin-proteasome system may help manage this stress. In Saccharomyces cerevisiae, UBI4 encodes five tandem ubiquitin monomers and is essential for growth in zinc-deficient conditions. Although UBI4 is only one of four ubiquitin-encoding genes in ...更多

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