Spherical crystallization of ketoprofen: effect of crystal texture and formulation on compaction density

Poorly-compressible crystals of ketoprofen were agglomerated by spherical crystallization with a two-solvent system (acetone/demineralized water). By varying the operating parameters (temperatures and concentrations), we have modified the shape and the internal texture of the particles obtained. On the other hand, preliminary screening of polymers highlighted three formulations with very low concentrations of additives. The micromeritic features of all these systems were studied to evaluate the improvement of compressibility and compactibility for direct tabletting.