PS 12-21 CARDIOVASCULAR MANIFESTATION AFTER LONG-TERM GLUCOCORTICOID ABUSERS FROM TRADITIONAL HERBAL DRINKS: A POPULATION BASED-STUDY

Objective: Analyze the relationship between long-term glucocorticoid abusers with cardiovascular manifestation in pre-elderly and elderly population at Mojoagung, a rural district in Jombang, INDONESIA. Design and Method: Cross-sectional study was conducted at Mojoagung District, Jombang with multi-stage cluster random sampling, collecting 63 samples. Data were collected by questionnaire to access history of consuming glucocorticoid from traditional herbal drinks and/or medication. Statistical analysis applied Pearson's correlation, Independent Sample t-test, Chi-square test with Coefficient Contigency. 63 subjects were composed of 19 pre-elderly (55–64 years old) and 44 elderly subjects (> 65 years old), 28.6% men and 71.4% women, with a mean age of 69.65 (± 10.07) years. Results: 18 subjects (28.6%) were steroid abusers for more than 30 years. Of the 18 abusers subjects, hypertension were found in 15 subjects (83.33%), whereas in 45 non-abusers subjects, hypertension were only found in 16 subjects (35.56%). There is a moderate relationship between long-term glucocorticoid abusers with hypertension (p=0.001, r = +0.396, PR 2.344 [1.503–3.655; 95% CI]). Results showed a significant increase in systolic and diastolic blood pressure (SBP and DBP) in glucocorticoid abusers which associates with duration of abuse (p = 0.02 and p = 0.03, respectively). No significant electrocardiography changes had been found. No major cardiovascular complication, ASCVD, Stroke, and Cardiomyopathy, and Hypoadrenal Crisis had been found during observation. Conclusions: Increase in SBP or DBP is a common complication of long-term glucocorticoid abusers which can lead serious cardiovascular manifestation. Glucocorticoid misuse is an important problem which has been inadequately addressed in the rural and semi-urban communities of Mojoagung District, Jombang - INDONESIA.