Visible light-mediated photodegradation of imidazoline drugs in the presence of Riboflavin: Possible undesired effects on imidazoline-based eye drops

Cecilia Challier,Daniel O. Mártire,Norman A. García,Susana Criado

Journal of Photochemistry and Photobiology A: Chemistry（2017）

引用 6|浏览5

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摘要

•Oxymetazoline and xylometazoline interacts with the excite states of Riboflavin.•Oxymetazoline is more easily photo-degradable than xylometazoline against ROS.•Upon direct UV- irradiation oxymetazoline and xylometazoline generate O2(1Δg).

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关键词

Ophthalmic drugs,Imidazoline derivatives,Riboflavin,Reactive oxygen species,Degradation

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