GW27-e1160 Ultrasound-targeted Microbubble Destruction Enhances the PHD2-shRNA to restore Myocardial Function following Ischemic Injury in Rats via Improving the Efficacy of Therapeutic Angiogenesis

We hypothesize that the inhibition of HIF-1α degradation via short hairpin RNA (shRNA) knockdown of PHD2 using UTMD in rats would promote transgene expression, facilitate angiogenesis, improve myocardial function and provide a potential therapy for ischemic and reperfusion myocardial injury in rats