Cell Motility: Surface-Grafted Nanogel Arrays Direct Cell Adhesion and Motility (Adv. Mater. Interfaces 20/2016)

Antonio Sechi and co-workers describe the fabrication of highly functional and stimuli-responsive nanogel arrays grafted onto glass surfaces by a printing process using wrinkled PDMS templates in article 1600455. These nanogels influence size and dynamics of focal adhesions as well as cell motility forcing cells to move along highly directional trajectories. The modulation of nanogel topographical and mechanical properties by temperature or spacing serves as an effective tool for the regulation of cell motility.