Pharmacokinetic interaction of brivaracetam on carbamazepine in adult patients with epilepsy, with and without valproate co-administration

•Phase I open-label study in 18 adults with epilepsy taking carbamazepine±valproate.•Brivaracetam 100 and 200mg bid approximately doubled plasma carbamazepine epoxide.•Data consistent with dose-dependent inhibition of epoxide hydrolase by brivaracetam.•Carbamazepine-epoxide concentrations ∼0.7μg/mL higher in the presence of valproate.•There is no need to limit brivaracetam dosing when used concomitantly with carbamazepine.