Benzylideneoxymorphone: A new lead for development of bifunctional mu/delta opioid receptor ligands
Bioorganic & Medicinal Chemistry Letters(2017)
摘要
Opioid analgesic tolerance remains a considerable drawback to chronic pain management. The finding that concomitant administration of delta opioid receptor (DOR) antagonists attenuates the development of tolerance to mu opioid receptor (MOR) agonists has led to interest in producing bifunctional MOR agonist/DOR antagonist ligands. Herein, we present 7-benzylideneoxymorphone (6, UMB 246) displaying MOR partial agonist/DOR antagonist activity, representing a new lead for designing bifunctional MOR/DOR ligands.
更多查看译文
关键词
Mu opioid receptor,Delta opioid receptor,Analgesic tolerance,Oxymorphone,Benzylideneoxymorphone
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要