Gender Effect On Non-Motor Symptoms In Parkinson'S Disease: Are Men More At Risk For Most Of Them?

•We evaluated the burden of non-motor symptoms (NMS) in PD and the possible gender differences in their occurrence.•585 PD patients and 481 age-matched controls underwent a face-to-face interview and a neurological examination.•All NMS were significantly more frequent among PD patients than controls.•With respect to controls, PD men showed a stronger positive significant association with almost all NMS compared to women.•The presence of NMS in PD is more related to neurodegeneration than ageing and the risk of NMS in PD is greater for men.