Synthesis and Antimicrobial Activity of Some Taurinamide Derivatives

In this study, a series of taurinamide derivatives were synthesized and screened for their antimicrobial activity. The structures of the newly synthesized compounds 11 - 15 were evaluated by 1 H NMR, IR, APCI, elemental analysis. Compounds 1-15 were tested against standart strains of G(+), G(−) bacteria and fungi by using disc diffusion and broth microdilution methods. Although disc diffusion method did not show any comparable results due to the solubility properties of the compounds; microdilution method results indicated that title compounds showed from poor to good activity against only Enterococcus faecalis.  It can be concluded that phtalimido moiety, secondary aryl sulphonamide group and electron-donating group substitution on phenyl ring are essential for the antibacterial activity. Among the tested compounds, para substituted methyl and methoxy derivatives of N -phenyl-2-phthalimidotaurinamide ( 4 , 7) , displayed equipotent activity compared to standard drug gentamicin.