Syntheses and antiproliferative activities of novel phosphatidylcholines containing dehydroepiandrosterone moieties

Marek Kłobucki,Aleksandra Grudniewska,Damian A. Smuga,Małgorzata Smuga,Joanna Jarosz,Joanna Wietrzyk,Gabriela Maciejewska,Czesław Wawrzeńczyk

Steroids（2017）

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摘要

•Novel phosphocholines containing DHEA were synthesized.•The antiproliferative activities of the novel phosphatidylcholines were studied.•Incorporating DHEA at the sn-1 or sn-2 position reduces drug toxicity against normal cells (Balb/3T3).•B16 and HL-60 cell lines were most sensitive to the tested phospholipids.

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关键词

Phospholipids,Dehydroepiandrosterone,Antiproliferative activity,Cytotoxic,HL-60,B16

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