Neurobiological consequences of juvenile stress: A GABAergic perspective on risk and resilience

Neuroscience & Biobehavioral Reviews(2017)

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摘要
•Childhood stress is an important risk factor for posttraumatic stress disorder.•Juvenile stress in rodents models human childhood stress.•Juvenile stress induces long-term alterations in GABAergic neurotransmission.•Some GABAergic changes may relate to allostasis rather than behavioral impairments.•Behavioral profiling tools allow to dissect resilience- and pathology-related changes.
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关键词
Juvenile stress,Posttraumatic stress disorder,Anxiety,GABAergic system,Dorsal and ventral hippocampus,Dentate gyrus,Corticosterone,HPA axis,Resilience,Behavioral profiling
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