The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity
NATURE CHEMICAL BIOLOGY（2017）
摘要
Editorial Summary SUV4-20 members mediate the di- and trimethylation of lysine 20 on histone H4. A chemical screen led to the identification of A-196 as a potent and selective inhibitor of SUV4-20 that decreases H4K20 methylation and alters DNA damage response.
更多查看译文
关键词
DNA damage and repair,Histone post-translational modifications,Small molecules,X-ray crystallography,Chemistry/Food Science,general,Biochemical Engineering,Biochemistry,Cell Biology,Bioorganic Chemistry
AI 理解论文
溯源树
样例
生成溯源树，研究论文发展脉络
Chat Paper
正在生成论文摘要