(+)-Pentazocine attenuates SH-SY5Y cell death, oxidative stress and microglial migration induced by conditioned medium from activated microglia

Kathrin Heiss,Marco Raffaele,Luca Vanella,Paolo Murabito,Orazio Prezzavento,Agostino Marrazzo,Giuseppina Aricò,Carlo Castruccio Castracani,Ignazio Barbagallo,Agata Zappalà,Roberto Avola,Giovanni Li Volti

Neuroscience Letters（2017）

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摘要

•(+)-Pentazocin, a σ1 agonist, inhibits microglial cell migration.•(+)-Pentazocin protects SH-SY5Y cells from microglia activation.•(+)-Pentazocin prevents oxidative stress and neuroinflammation following microglial activation.

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关键词

DTG,DTNB,CNS,Hsp70,IL-10,NO,LPS,PBS,ROS,SOD,TNF-α

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