Targeting androgen receptor with ASC-J9 attenuates cardiac injury and dysfunction in experimental autoimmune myocarditis by reducing M1-like macrophage

Wenhan Ma,Ya Wang,Shuai Lu,LianHua Yan,Fen Hu,Zhaohui Wang

Biochemical and Biophysical Research Communications（2017）

引用 11|浏览3

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摘要

•Androgen receptor (AR) was increased in EAM and primary located in macrophages.•ASC-J9, a enhancer of AR degradation, attenuated myocardial damage and inflammation in EAM.•ASC-J9 inhibit M1 macrophage polarization through SOCS1-STAT5 pathway in vitro.

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关键词

Androgen receptor,Experimental autoimmune myocarditis,Macrophage,SOCS1,STAT5

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