INTRARENAL RENIN ANGIOTENSIN SYSTEM ACTIVATION: PATHOPHYSIOLOGIC AND THERAPEUTIC IMPLICATIONS IN ACUTE DECOMPENSATED HEART FAILURE

Seethalakshmi Iyer,Denise M. Heublein,Sherry L. Benike, Laura Meems,Jeson S. Sangaralingham,John C. Burnett

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY（2017）

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摘要

Introduction: The Renin Angiotensin System (RAS) plays a pivotal role in mediating Cardiorenal Syndrome in acute decompensated heart failure (ADHF) and is one of the most targeted pathways in the treatment of HF. Human Angiotensinogen (AGT) is the precursor for all angiotensin (ANG) isoforms,

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