Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein
NATURE(2017)
摘要
Double electron–electron resonance and computer simulations are used to describe conformational dynamics in the ATP-binding cassette transporter Pgp, which has an important role in the clearance of xenobiotics and cancer resistance to chemotherapy.
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关键词
Permeation and transport,Structural biology,Science,Humanities and Social Sciences,multidisciplinary
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