Factors of Early Recurrence (<24 Months) in Relapsed Node Negative Early Stage Breast Cancer (the Study of Anatolian Society of Medical Oncology).

e12066 Background: Recurrence is a important cause of morbidity and mortality in the early stage of breast cancer. Although the node positivity more tightly associated with recurrence, it can be observed in node negative patients. In this study, we evaluated determining factors for early recurrence in node negative operated breast cancer patients. Methods: Between 1998 to 2012, relapsed node negative operated breast cancer patients were included in the study from referral centers. Patients divided into two groups; early recurrence ( ≤ 24 months) and late recurrence ( > 24 months) group. Results: A total of 290 patients were included in the study. While 108 of the 290 patients (37.2%) were in the early recurrence group, 182 (62.8%) were in the late recurrence group. The median age was 51 (21-87), invasive ductal carcinoma histology, the proportion of grade 3 patients, and lymphovascular invasion (LVI) ratio were 83.8%, 33.7%, and 41.3%, respectively. Estrogen Receptor (ER), Progesterone Receptor (PR) and Human Epidermal Growth Receptor 2 (HER2) positivity were 60.4%, 61.8% and 30%, respectively. Although, there were no statistical differences between early and late recurrence groups in terms of age (median 52 (21-82) vs. 50 (21-87), p = 0.503), histological subtypes (invasive ductal carcinoma ratio, 80.6 % and 85.7 %, respectively, p = 0.417) , tumor stage (T3,4 patients ratio 18.3% and 10.6 %, p = 0.102 ) and LVI (43.9 % and 39.6 %, p = 0.634 ), significant differences were observed in terms of grade (grade 3 patients ratio; 47.0 % vs 25.2 % , p < 0.001), ER positivity (41.1 % vs. 71.8 %, p < 0.001), PR positivity (50.0% vs. 68.9%, p = 0.001 ] and HER2 positivity (36.1% vs. 25.8%, p = 0.064). Statistically significant parameters in the univariate analyze were evaluated in multivariate analysis and ER negativity [ Odds Ratio (OR) : 2.68 , 95% CI ; 1.40 to 5.12 , p = 0.003 ], and the presence of grade 3 disease (OR: 2.27 , 95% CI , 1.28 to 4.02 , p = 0.005) were found as independent prognostic factors. Conclusions: In this study, ER negativity and grade 3 disease were found as independent prognostic factor and these parameters can be used in order to predict recurrence in early stage node negative breast cancer patients.