Association of chromosome complexity with age and metastasis in synovial sarcomas: Validation of expression and genomic prognostic signatures.

9536 Background: Synovial sarcoma (SS) is one of the rare sarcomas that occurs in adolescents as well as in adults. Nevertheless, metastasis occurs with a lowest frequency in the former, 10 vs 50% respectively. In almost all cases, a characteristic translocation t(X;18)(p11.2;q11.2) exists and the importance of this translocation in SS oncogenesis is well established, but the genetic basis of SS metastasis is still poorly understood. We recently published expression (CINSARC) and genomic (GI) signatures related to chromosome integrity control that predict outcome in undifferentiated sarcomas and GIST and ask whether these signatures could also predict outcome in SS. Methods: To asses this issue we selected in the European sarcoma database CONTICABASE 92 primary untreated SS for expression and genomic profiling. Results: As demonstrated by metastasis-free survival, CINSARC and GI have strong and independent prognostic values (p = 1.6 x 10-5 and p = 4 x 10-6, respectively). Comparing expression profiles of ...