Phase 2 trial of everolimus and letrozole in relapsed estrogen receptor-positive high-grade ovarian cancers

Gerardo Colon-Otero,S. John Weroha,Nathan R. Foster,Paul Haluska,Xiaonan Hou,Andrea E. Wahner-Hendrickson,Aminah Jatoi,Matthew S. Block,T.A. Dinh,Matthew W. Robertson,John A. Copland

Gynecologic Oncology（2017）

引用 31|浏览29

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摘要

•AI therapy is associated with limited clinical activity in high-grade ovarian cancer.•Combination of everolimus and letrozole is associated with a promising12-week PFS.•PDX tumor models can be generated from biopsies of ovarian tumors.

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关键词

Ovarian cancer,Everolimus,Aromatase inhibitors,PDX models

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