Expert Opinion on the Management of Intracerebroventricular (ICV) Drug Delivery

Background: The intracerebroventricular (ICV) route of administration has been used for many decades to treat pediatric and adult patients with a broad range of central nervous system (CNS) disorders. There is no consensus in management of ICV devices and associated rates of reported complications are highly variable. A systematic literature review revealed that noninfectious complication rates per patient range from 1 to 33%, while infectious complication rates range from 0 to 27%.