Interaction of Helicobacter Pylori with Other Microbiota Species in the Development of Gastric Cancer

Background/aim: increasing number of multidrug-resistant (MDR) bacteria and the need synthesize new antimicrobials, nanoparticles have attracted interest in the scientific community. This study aimed evaluate the effect of nanoparticles with antibiotics against MDR pathogenic bacteria.Material and methods: Seventeen bacterial isolates including; Escherichia coli (n=5) and Klebsiella pneumoniae (n=12) collected from different clinical samples of patients suffering from burn wound and fistulae wounds infections. The susceptibility of the collected isolates different antibiotics was investigated. Six MDR isolates selected as representatives different patterns used the determination of the antibacterial activities of two metals nanoparticles; silver (Ag-NPs) and zinc oxide (ZnO-NPs). antibacterial activities of the nanoparticles alone and their with the selected antibiotics were determined against the tested isolates using disc-diffusion method according to EUCAST Clinical Breakpoint.Results: Well dispersed spherical Ag-NPs with average particle size 12.65 ± 0.55 nm and ZnO-NPs of 7.6 ± 0.5 nm chemically synthesized by the reduction method and chemical precipitation method, respectively. obtained results suggested that the Ag-NPs alone had higher antibacterial activity ZnO-NPs. Furthermore, Ag-NPs show an observable synergistic effect with some antibiotics; more than ZnO-NPs.Conclusions: It was concluded that Ag-NPs have potential as a combination therapeutic agent for the treatment of infectious diseases by bacteria.