The Relationship Between Fractional Lymphocyte Counts And Survival In Malignant Melanoma.

e20116 Background: While strong evidence supports a relationship between acquired immune deficiency states and virus-associated malignancy, the relationship between immune function and epithelial malignancy in the setting of immunocompetence is less clear. In malignant melanoma, the success of lymphocyte-targeted immunotherapies suggest that lymphocyte immunity may play a role disease outcomes. Separate evidence suggests that immunosenescence in old age is associated with impaired lymphocyte immunity. We hypothesized that fractional lymphocyte counts are associated with survival in melanoma, and that this relationship is likely to be stronger in younger as compared to older individuals. Methods: We retrospectively examined the relationship between peripheral blood immune indices and survival in malignant melanoma. We identified individuals who had died from malignant melanoma in our unit over the past 2 years. We recorded pre-treatment neutrophil, lymphocyte, and total white cell counts. Survival time fro...