Prediction Of Treatment Response In Subtypes Of Non-Hodgkin'S Lymphoma By In Vivo P-31 Mr Spectroscopy Before Treatment

8565 Background: To determine if the intracellular tumor marker of phosphoethanolamine plus phosphocholine normalized by nucleotide triphosphates (PPN) monitored non-invasively by phosphorus MR spectroscopy (31P-MRS) correlate with indicators of treatment response in non-Hodgkinu0027s lymphoma (NHL) subtypes. Methods: The PPN value was obtained in 33 diffuse large B-cell lymphomas (DLBCL), 18 follicular lymphomas (FL) and 16 other types (OT) of NHL using in vivo 3D-localized, 1H-irradiated 31P-MRS prior to standard treatment. Results: The PPN values (mean ± standard error) for complete responses (CR) and not complete responses (NCR) in DLBCL were significantly different (CR: 1.42±0.10, n=19 and NCR: 2.25±0.15, n=14; pu003c0.00002). A Fisher test with a cutoff maximizing PPN sensitivity and specificity (1.78) showed a pu003c0.004 (sensitivity=0.6, specificity=1.0). Further, when the PPN was combined with the international prognostic index (IPI) to predict treatment response, the Fisher test increased significance (pu003c0...