1H and 19F NMR in drug stress testing: the case of voriconazole
RSC Advances(2017)
摘要
Stress tests form an important part of drug development, and of subsequent accreditation. Commonly the change in chemical composition over time is determined using chromatographic methods that separate the mixture components, but when structural characterization of the degradation products is required, other methods are needed. Arguably the most powerful method for determining chemical structure information is NMR spectroscopy. Here we show that NMR alone, using a combination of simple 19F, 1H, and DOSY experiments, can characterise both structure and kinetics of an intact reaction mixture, without the need for any physical separation.
更多查看译文
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要