Novel Complex I inhibitor IACS-010759 Targets Leukemia Initiating Cells (LICs) in AML Patients

Natalia Baran,Lina Han,Shelley M. Herbrich,Shannon R. Sweeney,Alessia Lodi,Ningping Feng,Jennifer R. Molina,Marcin Kaminski,Monica L. Guzman,Gheath Alatrash,Stefano Tiziani,Joseph R. Marszalek,Marina Konopleva

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA（2017）

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摘要

Metabolic alterations in cancer have attracted interest as a therapeutic target. Recent studies showed that leukemia initiating cells (LICs) are highly dependent on oxidative phosphorylation (OxPhos).

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关键词

leukemia initiating cells,aml patients,inhibitor,lics

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