Single-molecule diffusion-based estimation of GPCR activity

bioRxiv, pp. 205161-46, 2017.

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Abstract:

G protein-coupled receptors (GPCRs) are major drug targets and have high potential for drug discovery. The development of a method for measuring the activities of GPCRs is essential for pharmacology and drug screening. However, it is difficult to measure the effects of a drug by monitoring the receptor on the cell surface, and changes in ...More

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