Predicting Dynamics of Cerebrospinal Fluid Biomarkers by Tap Test in Idiopathic Normal Pressure Hydrocephalus

Background: Idiopathic normal pressure hydrocephalus (iNPH) is one of common age-related neurological diseases. Approximately half of iNPH patients have coexisting pathology of Alzheimer’s disease. However, we previously reported that lower cerebrospinal fluid (CSF) tau levels were observed in iNPH. In previous reports, tau levels in ventricular CSF (VCSF) were significantly elevated compared to ones in lumbar CSF (LCSF) in iNPH.