Synthesis of Optically Pure (S,E)-2-Amino-5-arylpent-4-enoic Acids by Heck Reactions of Nickel Complexes

Silvio Parpart,Zorayr Z. Mardiyan,Peter Ehlers,Andranik Petrosyan,Anna F. Mkrtchyan,Ashot S. Saghyan,Peter Langer

SYNLETT（2018）

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摘要

Starting from commercially available building blocks a variety of enantiomerically pure (S)-2-amino-4-enoic acids has been synthesized by the Heck reaction using Ni-(S)-BPB {Nickel-N-[(S)-benzyl-prolyl] aminobenzophenone} as a chiral auxiliary. The reactions proceeded in very good yields and with high E-selectivity.

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关键词

amino acids,Heck reaction,catalysis,chiral auxiliary,enantioselectivity

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