Synthesis and antibacterial activity of oxazolidinone derivatives containing nitro heteroaromatic moiety

A series of novel oxazolidinone derivatives containing nitro heteroaromatic moiety was synthesized and characterized by means of 1 H NMR and MS spectra. All target compounds were evaluated for their in vitro antibac-terial activities against S.au 29213, methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) by minimum inhibitory concentration(MIC) assay. Most of them exhibited antibacterial activity against S.au 29213, MRSA and VRE. Among them, compounds 10 e and 10 f displayed better activity than the control.