A New Pair of Pentaketide Diastereoisomers from Aspergillus melleus YIM PHI001

Two new aspinotriol derivatives (1-2) determined as melleusin A (1), B (2) and other seven known compounds were isolated from a soil-borne fungus Aspergillus melleus. The configurations of 1, and 2 were determined by their analogues, aspilactonol B, C isolated previous in Aspergillus. Mellein (8) showed broad antibiotic activity against the test pathogens. Aspinonene, aspinotriols A and B can be used as the marker molecule in chemotaxonomy of Aspergillus.