Encapsulated organoids & organ-on-a-chip platform for cancer modeling
2017 IEEE International Electron Devices Meeting (IEDM)(2017)
摘要
This review highlights our major developments in the fields of organoids and organ-on-chip to address issues in fundamental and biomedical research by modeling development and cancer. We illustrate how contemporary miniaturized technologies (microfluidics, 3D scaffolding, 3D imaging) combined with RNAi-based organoids HTS (High-Throughput Screening), would help forming and analyzing consistent, efficient and reproducible organoids. Moreover, we illustrate the potential of engineered organ-on-chip devices for creating novel human organ and disease models, with particular focus on “prostate-on-a-chip”.
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关键词
3D organoids,pencapsulation,3D lensfree imaging,single-cell genomics,3D scaffolding,prostate cancer
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