Race, Ethnicity, Socioeconomic Status and Site-specific Risk for Gastric Cancer

Differences in gastric cancer risk by race/ethnicity have been reported but data on risk by anatomic subsite are lacking. We assessed site-specific differences in gastric cancer risk according to race/ethnicity and socioeconomic status. Methods: Participants included incident cases of gastric adenocarcinoma age u003e18 years in the Surveillance Epidemiology and End Results Program 2000–2014. Primary outcome was risk for incident gastric cancer, overall, and by anatomic subsite (cardia vs. non-cardia). Age-adjusted incidence rates were used to estimate adjusted incidence rate ratios (IRR) and their 95% confidence intervals (CI). Risk was assessed by race/ethnicity and neighborhood socioeconomic status (nSES). Results: We identified 77,881 cases of incident gastric cancer ( n = 23,651 cardia; n = 35,825 non-cardia; n = 18,405 other). For all gastric cancers, adjusted IRRs (95% CI) were higher for blacks [1.72 (95% CI: 1.68–1.76)], Hispanics [1.77 (1.73–1.80)], and Asian/Pacific Islanders [2.12 (2.08–2.17)] compared to non-Hispanic whites. Opposite trends in risk for cardia vs. non-cardia cancer by race/ethnicity were observed. Compared to non- Hispanic whites, cardia IRRs (95% CI) were 0.55 (0.52–0.59) for blacks, 0.63 (0.60–0.66) for Hispanics, and 0.59 (0.56–0.62) for Asians/Pacific Islanders. Non-cardia IRRs (95% CI) were 2.78 (2.69–2.87) for blacks, 2.83 (2.75- 2.91) for Hispanics, and 3.86 (3.75–3.97) for Asians/Pacific Islanders relative to non-Hispanic whites. Increasing risk with decreasing nSES was observed for all gastric cancers (p trend