The Effect of Intravenous Administration of Ondansetron on Analgesia Time of Caudal Block in Circumcision Cases: A Randomized Controlled Trial

We investigate whether there was any effect of intravenous ondansetron administered for postoperative nausea vomiting prophylaxis on the duration of caudal block action in patients who undergo circumcision surgery. 66 ASA I–II patients aged 4 to 10 and scheduled for circumcision surgery were included in this prospective, randomized controlled study. We administered 0.1 mg/kg ondansetron IV to Group Ondansetron patients before caudal block and same amount of serum physiologic for Group Control patients. After anesthesia induction caudal block with 1 ml/kg 0.25% bupivacaine administered. We evaluated postoperative analgesia durations in each group. There were no difference between groups for number of patients which were painless for first 4 hours and 8 hours, total analgesic requirements for first 24 hours, total time for first analgesic requirements. We concluded that iv ondansetron given at 0.1 mg/kg dose before caudal block with bupivacaine can be used safely without a significant effect on the duration of block-induced analgesia.